Investigation of the Effect of Uridine on MCF-7 Breast Adenocarcinoma Cells

Abstract

Objective: Diet is one of the environmental factors in the development of cancer and it has a great role in this development. Our aim is to investigate the dietary uridine on MCF-7 breast adenocarcinoma cells.

Method: In uridine and MCF-7 cell culture, 2 groups were planned as control group and drug group. While no application was made to the control group, various concentrations (100, 250, 500, 1000 μM) of uridine were applied to the drug group for 24 hours. The effect of uridine on cell proliferation was determined by XTT cell viability test.

Results: According to the XTT data obtained, uridine at the doses we studied did not have a statistically significant effect on MCF-7 breast adenocarcinoma cells in terms of cell viability (p>0.05).

Conclusions: Our results showed that uridine had no antiproliferative effect on the MCF-7 cell line.