Antiproliferative Effect of Galium Aparine on C6 Glioma Cells

Galium Aparine’nin Antiproliferatif Etkisi

Abstract

Aim: Primary brain tumours account for 2% of all cancer-related mortality rates. Despite various treatment modalities, the average life expectancy is 1 year. Glioblastoma multiforme (GBM), one of the primary brain tumours, is a highly dangerous brain tumour that spreads rapidly in the brain tissue and destroys the tissue. C6 cell lines are widely used in neuro-oncology as they can reflect the characteristics of human glioma such as invasion, migration, tumourigenesis and angiogenesis. Galium Aparine (GA) is a plant known as ‘yoghurt herb’ in Anatolia. Studies have reported that GA has antimicrobial, antioxidant and anticancer effects. However, the antiproliferative effect of GA on GBM is not known. This study investigated the possible anticancer activity of GA on C6 cells.

Methods: The C6 glioma cell line was used in this study. To evaluate the anticancer activity of GA in C6 cells, various concentrations (6.25, 12.5, 25, 50 and 100 μg/ml) were applied to the cells and incubated for 24 hours. Cell viability was evaluated by XTT assay.

Results: GA significantly decreased C6 glioma cell survival at 100, 50 and 25 μg/ml concentrations.

Conclusions: GA significantly decreased cell viability in C6 glioma cells.